Fibroblast Growth Factor-2 (FGF-2) Induces Vascular Endothelial Growth Factor (VEGF) Expression in the Endothelial Cells of Forming Capillaries: An Autocrine Mechanism Contributing to Angiogenesis

FGF-2 and VEGF are potent angiogenesis inducers in vivo and in vitro. Here we show that FGF-2 induces VEGF expression in vascular endothelial cells through autocrine and paracrine mechanisms. Addition of recombinant FGF-2 to cultured endothelial cells or upregulation of endogenous FGF-2 results in i...

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Main Authors: Seghezzi, Graziano, Patel, Sundeep, Ren, Christine J., Gualandris, Anna, Pintucci, Giuseppe, Robbins, Edith S., Shapiro, Richard L., Galloway, Aubrey C., Rifkin, Daniel B., Mignatti, Paolo
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 1998
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2132998/
https://ncbi.nlm.nih.gov/pubmed/9647657
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