Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

The prohibitin (PHB)-domain proteins are membrane proteins that regulate a variety of biological activities, including mechanosensation, osmotic homeostasis, and cell signaling, although the mechanism of this regulation is unknown. We have studied two members of this large protein family, MEC-2, whi...

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Hlavní autoři: Huber, Tobias B., Schermer, Bernhard, Müller, Roman Ulrich, Höhne, Martin, Bartram, Malte, Calixto, Andrea, Hagmann, Henning, Reinhardt, Christian, Koos, Fabienne, Kunzelmann, Karl, Shirokova, Elena, Krautwurst, Dietmar, Harteneck, Christian, Simons, Matias, Pavenstädt, Hermann, Kerjaschki, Dontscho, Thiele, Christoph, Walz, Gerd, Chalfie, Martin, Benzing, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1859892/
https://ncbi.nlm.nih.gov/pubmed/17079490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607465103
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