Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

The prohibitin (PHB)-domain proteins are membrane proteins that regulate a variety of biological activities, including mechanosensation, osmotic homeostasis, and cell signaling, although the mechanism of this regulation is unknown. We have studied two members of this large protein family, MEC-2, whi...

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Hauptverfasser: Huber, Tobias B., Schermer, Bernhard, Müller, Roman Ulrich, Höhne, Martin, Bartram, Malte, Calixto, Andrea, Hagmann, Henning, Reinhardt, Christian, Koos, Fabienne, Kunzelmann, Karl, Shirokova, Elena, Krautwurst, Dietmar, Harteneck, Christian, Simons, Matias, Pavenstädt, Hermann, Kerjaschki, Dontscho, Thiele, Christoph, Walz, Gerd, Chalfie, Martin, Benzing, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1859892/
https://ncbi.nlm.nih.gov/pubmed/17079490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607465103
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