Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

The prohibitin (PHB)-domain proteins are membrane proteins that regulate a variety of biological activities, including mechanosensation, osmotic homeostasis, and cell signaling, although the mechanism of this regulation is unknown. We have studied two members of this large protein family, MEC-2, whi...

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Autori principali: Huber, Tobias B., Schermer, Bernhard, Müller, Roman Ulrich, Höhne, Martin, Bartram, Malte, Calixto, Andrea, Hagmann, Henning, Reinhardt, Christian, Koos, Fabienne, Kunzelmann, Karl, Shirokova, Elena, Krautwurst, Dietmar, Harteneck, Christian, Simons, Matias, Pavenstädt, Hermann, Kerjaschki, Dontscho, Thiele, Christoph, Walz, Gerd, Chalfie, Martin, Benzing, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1859892/
https://ncbi.nlm.nih.gov/pubmed/17079490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607465103
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