Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

The prohibitin (PHB)-domain proteins are membrane proteins that regulate a variety of biological activities, including mechanosensation, osmotic homeostasis, and cell signaling, although the mechanism of this regulation is unknown. We have studied two members of this large protein family, MEC-2, whi...

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Detalhes bibliográficos
Main Authors: Huber, Tobias B., Schermer, Bernhard, Müller, Roman Ulrich, Höhne, Martin, Bartram, Malte, Calixto, Andrea, Hagmann, Henning, Reinhardt, Christian, Koos, Fabienne, Kunzelmann, Karl, Shirokova, Elena, Krautwurst, Dietmar, Harteneck, Christian, Simons, Matias, Pavenstädt, Hermann, Kerjaschki, Dontscho, Thiele, Christoph, Walz, Gerd, Chalfie, Martin, Benzing, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1859892/
https://ncbi.nlm.nih.gov/pubmed/17079490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607465103
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