Mimicking dominant negative inhibition of prion replication through structure-based drug design
Recent progress determining the structure of the host-encoded prion protein (PrP(C)) and the role of auxiliary molecules in prion replication permits a more rational approach in the development of therapeutic interventions. Our objective is to identify a new class of lead compounds that mimic the do...
שמור ב:
| הוצא לאור ב: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2000
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18560/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10823951/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.11.6073 |
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