Mimicking dominant negative inhibition of prion replication through structure-based drug design
Recent progress determining the structure of the host-encoded prion protein (PrP(C)) and the role of auxiliary molecules in prion replication permits a more rational approach in the development of therapeutic interventions. Our objective is to identify a new class of lead compounds that mimic the do...
Сохранить в:
| Опубликовано в:: | Proc Natl Acad Sci U S A |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2000
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18560/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10823951/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.11.6073 |
| Метки: |
Нет меток, Требуется 1-ая метка записи!
|