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Mimicking dominant negative inhibition of prion replication through structure-based drug design

Recent progress determining the structure of the host-encoded prion protein (PrP(C)) and the role of auxiliary molecules in prion replication permits a more rational approach in the development of therapeutic interventions. Our objective is to identify a new class of lead compounds that mimic the do...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Perrier, Véronique, Wallace, Andrew C., Kaneko, Kiyotoshi, Safar, Jiri, Prusiner, Stanley B., Cohen, Fred E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18560/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10823951/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.11.6073
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