Parkin Localizes to the Lewy Bodies of Parkinson Disease and Dementia with Lewy Bodies

Mutations in α-synuclein (αS) and parkin cause heritable forms of Parkinson disease (PD). We hypothesized that neuronal parkin, a known E3 ubiquitin ligase, facilitates the formation of Lewy bodies (LBs), a pathological hallmark of PD. Here, we report that affinity-purified parkin antibodies labeled...

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Main Authors: Schlossmacher, Michael G., Frosch, Matthew P., Gai, Wei Ping, Medina, Miguel, Sharma, Nutan, Forno, Lysia, Ochiishi, Tomoyo, Shimura, Hideki, Sharon, Ronit, Hattori, Nobutaka, Langston, J. William, Mizuno, Yoshikuni, Hyman, Bradley T., Selkoe, Dennis J., Kosik, Kenneth S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2002
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Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850875/
https://ncbi.nlm.nih.gov/pubmed/12000718
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