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New Alzheimer’s disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers

Oligomers of intracellular amyloid β protein (Aβ) are strongly cytotoxic and play crucial roles in synaptic transmission and cognitive function in Alzheimer’s disease (AD). However, there is currently no AD model mouse in which to specifically analyze the function of Aβ oligomers only. We have now d...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Ochiishi, Tomoyo, Kaku, Masami, Kiyosue, Kazuyuki, Doi, Motomichi, Urabe, Takao, Hattori, Nobutaka, Shimura, Hideki, Ebihara, Tatsuhiko
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874556/
https://ncbi.nlm.nih.gov/pubmed/31757975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53415-8
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