Development of new fusion proteins for visualizing amyloid-β oligomers in vivo

The intracellular accumulation of amyloid-β (Aβ) oligomers critically contributes to disease progression in Alzheimer’s disease (AD) and can be the potential target of AD therapy. Direct observation of molecular dynamics of Aβ oligomers in vivo is key for drug discovery research, however, it has bee...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Ochiishi, Tomoyo, Doi, Motomichi, Yamasaki, Kazuhiko, Hirose, Keiko, Kitamura, Akira, Urabe, Takao, Hattori, Nobutaka, Kinjo, Masataka, Ebihara, Tatsuhiko, Shimura, Hideki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793674/
https://ncbi.nlm.nih.gov/pubmed/26982553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22712
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