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SirT3 is a nuclear NAD(+)-dependent histone deacetylase that translocates to the mitochondria upon cellular stress

In humans, there are at least seven Sir2-like proteins (SirT1–7) with diverse functions, including the regulation of chromatin structure, and metabolism. SirT3 levels have been shown to correlate with extended life span, to localize to the mitochondria, and to be highly expressed in brown adipose ti...

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Bibliografiske detaljer
Main Authors: Scher, Michael B., Vaquero, Alejandro, Reinberg, Danny
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847710/
https://ncbi.nlm.nih.gov/pubmed/17437997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1527307
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