SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

The mammalian cytoplasmic protein SirT2 is a member of the Sir2 family of NAD(+)-dependent protein deacetylases involved in caloric restriction-dependent life span extension. We found that SirT2 and its yeast counterpart Hst2 have a strong preference for histone H4K16Ac in their deacetylation activi...

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Autors principals: Vaquero, Alejandro, Scher, Michael B., Lee, Dong Hoon, Sutton, Ann, Cheng, Hwei-Ling, Alt, Frederick W., Serrano, Lourdes, Sternglanz, Rolf, Reinberg, Danny
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2006
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472900/
https://ncbi.nlm.nih.gov/pubmed/16648462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1412706
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