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XK469, a selective topoisomerase IIβ poison
XK469 (NSC 697887) is a synthetic quinoxaline phenoxypropionic acid derivative that possesses unusual solid tumor selectivity and activity against multidrug-resistant cancer cells. We report here that XK469 and its S(−) and R(+)-isomers induce reversible protein-DNA crosslinks in mammalian cells. Un...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The National Academy of Sciences
1999
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC18430/ https://ncbi.nlm.nih.gov/pubmed/10518594 |
| タグ: |
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