XK469, a selective topoisomerase IIβ poison

XK469 (NSC 697887) is a synthetic quinoxaline phenoxypropionic acid derivative that possesses unusual solid tumor selectivity and activity against multidrug-resistant cancer cells. We report here that XK469 and its S(−) and R(+)-isomers induce reversible protein-DNA crosslinks in mammalian cells. Un...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Gao, Hanlin, Huang, Kuan-Chun, Yamasaki, Edith F., Chan, Kenneth K., Chohan, Lubna, Snapka, Robert M.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC18430/
https://ncbi.nlm.nih.gov/pubmed/10518594
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars