XK469, a selective topoisomerase IIβ poison

XK469 (NSC 697887) is a synthetic quinoxaline phenoxypropionic acid derivative that possesses unusual solid tumor selectivity and activity against multidrug-resistant cancer cells. We report here that XK469 and its S(−) and R(+)-isomers induce reversible protein-DNA crosslinks in mammalian cells. Un...

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Main Authors: Gao, Hanlin, Huang, Kuan-Chun, Yamasaki, Edith F., Chan, Kenneth K., Chohan, Lubna, Snapka, Robert M.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC18430/
https://ncbi.nlm.nih.gov/pubmed/10518594
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