Lycobetaine acts as a selective topoisomerase IIβ poison and inhibits the growth of human tumour cells

The phenanthridine alkaloid lycobetaine is a minor constituent of Amaryllidaceae. Inhibition of cell growth was studied in the clonogenic assay on 21 human tumour xenografts (mean IC (50) = 0.8 μM). The growth of human leukaemia cell lines was also potently inhibited (mean IC (50) = 1.3 μM). Athymic...

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Dettagli Bibliografici
Autori principali: Barthelmes, H U, Niederberger, E, Roth, T, Schulte, K, Tang, W C, Boege, F, Fiebig, H-H, Eisenbrand, G, Marko, D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2001
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Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363954/
https://ncbi.nlm.nih.gov/pubmed/11720449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.2142
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