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Lycobetaine acts as a selective topoisomerase IIβ poison and inhibits the growth of human tumour cells
The phenanthridine alkaloid lycobetaine is a minor constituent of Amaryllidaceae. Inhibition of cell growth was studied in the clonogenic assay on 21 human tumour xenografts (mean IC (50) = 0.8 μM). The growth of human leukaemia cell lines was also potently inhibited (mean IC (50) = 1.3 μM). Athymic...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group
2001
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2363954/ https://ncbi.nlm.nih.gov/pubmed/11720449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.2142 |
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