An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function

Heat shock protein 90 (Hsp90) chaperones a key subset of signaling proteins and is necessary for malignant transformation. Hsp90 is subject to an array of post-translational modifications which affect its function, including acetylation. Histone deacetylase (HDAC) inhibitors and knock-down of HDAC6...

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Autori principali: Scroggins, Bradley T., Robzyk, Kenneth, Wang, Dongxia, Marcu, Monica G., Tsutsumi, Shinji, Beebe, Kristin, Cotter, Robert J., Felts, Sara, Toft, David, Karnitz, Larry, Rosen, Neal, Neckers, Len
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1839984/
https://ncbi.nlm.nih.gov/pubmed/17218278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.12.008
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