NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T cell development and in the pathogenesis over 50% of human T cell lymphoblastic leukemia (T-ALL) cases. However, little is known about the transcrip...

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Bibliografiska uppgifter
Huvudupphovsmän: Palomero, Teresa, Lim, Wei Keat, Odom, Duncan T., Sulis, Maria Luisa, Real, Pedro J., Margolin, Adam, Barnes, Kelly C., O'Neil, Jennifer, Neuberg, Donna, Weng, Andrew P., Aster, Jon C., Sigaux, Francois, Soulier, Jean, Look, A. Thomas, Young, Richard A., Califano, Andrea, Ferrando, Adolfo A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2006
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838740/
https://ncbi.nlm.nih.gov/pubmed/17114293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606108103
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