Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKα kinases

Little is known about the regulation and function of the Notch1 gene in negative control of human tumors. Here we show that Notch1 gene expression and activity are substantially down-modulated in keratinocyte cancer cell lines and tumors, with expression of this gene being under p53 control in these...

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Bibliografski detalji
Glavni autori: Lefort, Karine, Mandinova, Anna, Ostano, Paola, Kolev, Vihren, Calpini, Valerie, Kolfschoten, Ingrid, Devgan, Vikram, Lieb, Jocelyn, Raffoul, Wassim, Hohl, Daniel, Neel, Victor, Garlick, Jonathan, Chiorino, Giovanna, Dotto, G. Paolo
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2007
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820898/
https://ncbi.nlm.nih.gov/pubmed/17344417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1484707
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