The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response

Notch signalling has an important role in skin homeostasis, promoting keratinocyte differentiation and suppressing tumorigenesis. Here we show that this pathway also has an essential anti-apoptotic function in the keratinocyte UVB response. Notch1 expression and activity are significantly induced, i...

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Autores principales: Mandinova, Anna, Lefort, Karine, di Vignano, Alice Tommasi, Stonely, Wesley, Ostano, Paola, Chiorino, Giovanna, Iwaki, Haruhi, Nakanishi, Jotaro, Dotto, G Paolo
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367396/
https://ncbi.nlm.nih.gov/pubmed/18388864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.45
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