The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response

Notch signalling has an important role in skin homeostasis, promoting keratinocyte differentiation and suppressing tumorigenesis. Here we show that this pathway also has an essential anti-apoptotic function in the keratinocyte UVB response. Notch1 expression and activity are significantly induced, i...

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Autors principals: Mandinova, Anna, Lefort, Karine, di Vignano, Alice Tommasi, Stonely, Wesley, Ostano, Paola, Chiorino, Giovanna, Iwaki, Haruhi, Nakanishi, Jotaro, Dotto, G Paolo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367396/
https://ncbi.nlm.nih.gov/pubmed/18388864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.45
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