Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKα kinases

Little is known about the regulation and function of the Notch1 gene in negative control of human tumors. Here we show that Notch1 gene expression and activity are substantially down-modulated in keratinocyte cancer cell lines and tumors, with expression of this gene being under p53 control in these...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Lefort, Karine, Mandinova, Anna, Ostano, Paola, Kolev, Vihren, Calpini, Valerie, Kolfschoten, Ingrid, Devgan, Vikram, Lieb, Jocelyn, Raffoul, Wassim, Hohl, Daniel, Neel, Victor, Garlick, Jonathan, Chiorino, Giovanna, Dotto, G. Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820898/
https://ncbi.nlm.nih.gov/pubmed/17344417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1484707
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados