EGFR signaling as a negative regulator of Notch1 gene expression : a differentiation/apoptosis control mechanism for proliferating keratinocytes and cancer cells

The Notch1 gene plays an important role in mammalian cell fate decision and tumorigenesis. Upstream control mechanisms for transcription of this gene are still poorly understood. In a chemical genetics screen for small molecule activators of Notch signaling, we identified Epidermal Growth Factor Rec...

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Bibliografiske detaljer
Main Authors: Kolev, Vihren, Mandinova, Anna, Guinea-Viniegra, Juan, Hu, Bing, Lefort, Karine, Lambertini, Chiara, Neel, Victor, Dummer, Reinhard, Wagner, Erwin F., Dotto, G. Paolo
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747621/
https://ncbi.nlm.nih.gov/pubmed/18604200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1750
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