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EGFR signaling as a negative regulator of Notch1 gene expression : a differentiation/apoptosis control mechanism for proliferating keratinocytes and cancer cells
The Notch1 gene plays an important role in mammalian cell fate decision and tumorigenesis. Upstream control mechanisms for transcription of this gene are still poorly understood. In a chemical genetics screen for small molecule activators of Notch signaling, we identified Epidermal Growth Factor Rec...
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| Main Authors: | , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2008
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747621/ https://ncbi.nlm.nih.gov/pubmed/18604200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1750 |
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