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Translation of the poly(A) tail plays crucial roles in nonstop mRNA surveillance via translation repression and protein destabilization by proteasome in yeast

mRNA surveillance system represses the expression of nonstop mRNA by rapid mRNA degradation and translation repression. Here we show that the level of protein product of nonstop mRNA containing a poly(A) tail was reduced 100-fold, and this reduction was due to rapid mRNA degradation, translation rep...

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Main Authors: Ito-Harashima, Sayoko, Kuroha, Kazushige, Tatematsu, Tsuyako, Inada, Toshifumi
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820893/
https://ncbi.nlm.nih.gov/pubmed/17344413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1490207
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