Nascent Peptide-dependent Translation Arrest Leads to Not4p-mediated Protein Degradation by the Proteasome

The potentially deleterious effects of aberrant mRNA lacking a termination codon (nonstop mRNA) are ameliorated by translation arrest, proteasome-mediated protein destabilization, and rapid mRNA degradation. Because polylysine synthesis via translation of the poly(A) mRNA tail leads to translation a...

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Hauptverfasser: Dimitrova, Lyudmila N., Kuroha, Kazushige, Tatematsu, Tsuyako, Inada, Toshifumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667721/
https://ncbi.nlm.nih.gov/pubmed/19204001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808840200
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