Nascent Peptide-dependent Translation Arrest Leads to Not4p-mediated Protein Degradation by the Proteasome

The potentially deleterious effects of aberrant mRNA lacking a termination codon (nonstop mRNA) are ameliorated by translation arrest, proteasome-mediated protein destabilization, and rapid mRNA degradation. Because polylysine synthesis via translation of the poly(A) mRNA tail leads to translation a...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Dimitrova, Lyudmila N., Kuroha, Kazushige, Tatematsu, Tsuyako, Inada, Toshifumi
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667721/
https://ncbi.nlm.nih.gov/pubmed/19204001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808840200
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares