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Upf1 stimulates degradation of the product derived from aberrant messenger RNA containing a specific nonsense mutation by the proteasome

Aberrant messenger RNAs containing a premature termination codon (PTC) are eliminated by the nonsense-mediated mRNA decay (NMD) pathway. Here, we show that a crucial NMD factor, up frameshift 1 protein (Upf1), is required for rapid proteasome-mediated degradation of an aberrant protein (PTC product)...

詳細記述

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書誌詳細
主要な著者: Kuroha, Kazushige, Tatematsu, Tsuyako, Inada, Toshifumi
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775173/
https://ncbi.nlm.nih.gov/pubmed/19798102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.200
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