Upf1 stimulates degradation of the product derived from aberrant messenger RNA containing a specific nonsense mutation by the proteasome

Aberrant messenger RNAs containing a premature termination codon (PTC) are eliminated by the nonsense-mediated mRNA decay (NMD) pathway. Here, we show that a crucial NMD factor, up frameshift 1 protein (Upf1), is required for rapid proteasome-mediated degradation of an aberrant protein (PTC product)...

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Hlavní autoři: Kuroha, Kazushige, Tatematsu, Tsuyako, Inada, Toshifumi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2009
Témata:
Scientific Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775173/
https://ncbi.nlm.nih.gov/pubmed/19798102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.200
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