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Translation of nonSTOP mRNA is repressed post-initiation in mammalian cells

We investigated the fate of aberrant mRNAs lacking in-frame termination codons (called nonSTOP mRNA) in mammalian cells. We found that translation of nonSTOP mRNA was considerably repressed although a corresponding reduction of mRNA was not observed. The repression appears to be post-initiation sinc...

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Detalhes bibliográficos
Main Authors: Akimitsu, Nobuyoshi, Tanaka, Junichi, Pelletier, Jerry
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864977/
https://ncbi.nlm.nih.gov/pubmed/17446866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601679
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