Pyrrolysine analogues as substrates for pyrrolysyl-tRNA synthetase

In certain methanogenic archaea a new amino acid, pyrrolysine (Pyl), is inserted at in-frame UAG codons in the mRNAs of some methyltransferases. Pyl is directly acylated onto a suppressor tRNA(Pyl) by pyrrolysyl-tRNA synthetase (PylRS). Due to the lack of a readily available Pyl source, we looked fo...

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Bibliographic Details
Main Authors: Polycarpo, Carla R., Herring, Stephanie, Bérubé, Amélie, Wood, John L., Söll, Dieter, Ambrogelly, Alexandre
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1817836/
https://ncbi.nlm.nih.gov/pubmed/17126325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2006.11.028
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