Rhomboid cleaves Star to regulate the levels of secreted Spitz

Intracellular trafficking of the precursor of Spitz (Spi), the major Drosophila EGF receptor (EGFR) ligand, is facilitated by the chaperone Star, a type II transmembrane protein. This study identifies a novel mechanism for modulating the activity of Star, thereby influencing the levels of active Spi...

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Autori principali: Tsruya, Rachel, Wojtalla, Alexandra, Carmon, Shari, Yogev, Shaul, Reich, Aderet, Bibi, Eitan, Merdes, Gunter, Schejter, Eyal, Shilo, Ben-Zion
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1817629/
https://ncbi.nlm.nih.gov/pubmed/17304216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601581
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