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Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases

We explore the role of differential compartmentalization of Rhomboid (Rho) proteases that process the Drosophila EGF receptor ligands, in modulating the amount of secreted ligand and consequently the level of EGF receptor (EGFR) activation. The mSpitz ligand precursor is retained in the ER, and is t...

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Библиографические подробности
Главные авторы: Yogev, Shaul, Schejter, Eyal D, Shilo, Ben-Zion
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367402/
https://ncbi.nlm.nih.gov/pubmed/18369317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.58
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