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Rhomboid cleaves Star to regulate the levels of secreted Spitz

Intracellular trafficking of the precursor of Spitz (Spi), the major Drosophila EGF receptor (EGFR) ligand, is facilitated by the chaperone Star, a type II transmembrane protein. This study identifies a novel mechanism for modulating the activity of Star, thereby influencing the levels of active Spi...

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Autores principales: Tsruya, Rachel, Wojtalla, Alexandra, Carmon, Shari, Yogev, Shaul, Reich, Aderet, Bibi, Eitan, Merdes, Gunter, Schejter, Eyal, Shilo, Ben-Zion
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1817629/
https://ncbi.nlm.nih.gov/pubmed/17304216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601581
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