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Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases

We explore the role of differential compartmentalization of Rhomboid (Rho) proteases that process the Drosophila EGF receptor ligands, in modulating the amount of secreted ligand and consequently the level of EGF receptor (EGFR) activation. The mSpitz ligand precursor is retained in the ER, and is t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yogev, Shaul, Schejter, Eyal D, Shilo, Ben-Zion
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367402/
https://ncbi.nlm.nih.gov/pubmed/18369317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.58
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