Dendritic cells with TGF-β1 differentiate naïve CD4(+)CD25(−) T cells into islet-protective Foxp3(+) regulatory T cells

CD4(+)CD25(+)Foxp3(+) regulatory T cells (T regs) are important for preventing autoimmune diabetes and are either thymic-derived (natural) or differentiated in the periphery outside the thymus (induced). Here we show that β-cell peptide-pulsed dendritic cells (DCs) from nonobese diabetic (NOD) mice...

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Autors principals: Luo, Xunrong, Tarbell, Kristin V., Yang, Hua, Pothoven, Kathryn, Bailey, Samantha L., Ding, Ruchuang, Steinman, Ralph M., Suthanthiran, Manikkam
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1815265/
https://ncbi.nlm.nih.gov/pubmed/17307871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611646104
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