Dendritic cell–expanded, islet-specific CD4(+) CD25(+) CD62L(+) regulatory T cells restore normoglycemia in diabetic NOD mice

Most treatments that prevent autoimmune diabetes in nonobese diabetic (NOD) mice require intervention at early pathogenic stages, when insulitis is first developing. We tested whether dendritic cell (DC)–expanded, islet antigen–specific CD4(+) CD25(+) suppressor T cells could treat diabetes at later...

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Huvudupphovsmän: Tarbell, Kristin V., Petit, Lucine, Zuo, Xiaopan, Toy, Priscilla, Luo, Xunrong, Mqadmi, Amina, Yang, Hua, Suthanthiran, Manikkam, Mojsov, Svetlana, Steinman, Ralph M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2007
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118426/
https://ncbi.nlm.nih.gov/pubmed/17210729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061631
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