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Dendritic cells are specialized accessory cells along with TGF-β for the differentiation of Foxp3(+) CD4(+) regulatory T cells from peripheral Foxp3(−) precursors

Foxp3(+)CD25(+)CD4(+) regulatory T cells are produced in the thymus (natural T regs) but can also differentiate from peripheral Foxp3(−)CD4(+) precursors (induced or adaptive T regs). We assessed antigen presenting cell (APC) requirements for the latter differentiation. With added transforming growt...

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Autori principali: Yamazaki, Sayuri, Bonito, Anthony J., Spisek, Radek, Dhodapkar, Madhav, Inaba, Kayo, Steinman, Ralph M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234777/
https://ncbi.nlm.nih.gov/pubmed/17699744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-088831
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