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Prion species barrier between the closely related yeast proteins is detected despite coaggregation

Prions are self-perpetuating and, in most cases, aggregation-prone protein isoforms that transmit neurodegenerative diseases in mammals and control heritable traits in yeast. Prion conversion requires a very high level of identity of the interacting protein sequences. Decreased transmission of the p...

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Autors principals: Chen, Buxin, Newnam, Gary P., Chernoff, Yury O.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1815260/
https://ncbi.nlm.nih.gov/pubmed/17296932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611158104
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