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Contributions of the Prion Protein Sequence, Strain, and Environment to the Species Barrier

Amyloid propagation requires high levels of sequence specificity so that only molecules with very high sequence identity can form cross-β-sheet structures of sufficient stringency for incorporation into the amyloid fibril. This sequence specificity presents a barrier to the transmission of prions be...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Sharma, Aditi, Bruce, Kathryn L., Chen, Buxin, Gyoneva, Stefka, Behrens, Sven H., Bommarius, Andreas S., Chernoff, Yury O.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714215/
https://ncbi.nlm.nih.gov/pubmed/26565023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.684100
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