Retroviral vector insertion sites associated with dominant hematopoietic clones mark “stemness” pathways

Evidence from model organisms and clinical trials reveals that the random insertion of retrovirus-based vectors in the genome of long-term repopulating hematopoietic cells may increase self-renewal or initiate malignant transformation. Clonal dominance of nonmalignant cells is a particularly interes...

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Main Authors: Kustikova, Olga S., Geiger, Hartmut, Li, Zhixiong, Brugman, Martijn H., Chambers, Stuart M., Shaw, Chad A., Pike-Overzet, Karin, de Ridder, Dick, Staal, Frank J. T., von Keudell, Gottfried, Cornils, Kerstin, Nattamai, Kalpana Jekumar, Modlich, Ute, Wagemaker, Gerard, Goodell, Margaret A., Fehse, Boris, Baum, Christopher
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2007
Teme:
Hematopoiesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1801061/
https://ncbi.nlm.nih.gov/pubmed/17119121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-08-044156
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