Cell-intrinsic and Vector-related Properties Cooperate to Determine the Incidence and Consequences of Insertional Mutagenesis

In gene therapeutic approaches targeting hematopoietic cells, insertional mutagenesis may provoke clonal dominance with potential progress to overt leukemia. To investigate the contribution of cell-intrinsic features and determine the frequency of insertional proto-oncogene activation, we sorted hem...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kustikova, Olga S, Schiedlmeier, Bernhard, Brugman, Martijn H, Stahlhut, Maike, Bartels, Stefan, Li, Zhixiong, Baum, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835258/
https://ncbi.nlm.nih.gov/pubmed/19532134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.134
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados