Stem Cell Marking With Promotor-deprived Self-inactivating Retroviral Vectors Does Not Lead to Induced Clonal Imbalance

Stable genetic modification of stem cells holds great promise for gene therapy and marking, but commonly used γ-retroviral vectors were found to influence growth/survival characteristics of hematopoietic stem cells (HSCs) by insertional mutagenesis. In this article, we show that promoter-deprived γ-...

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Detalhes bibliográficos
Main Authors: Cornils, Kerstin, Lange, Claudia, Schambach, Axel, Brugman, Martijn H, Nowak, Regine, Lioznov, Michael, Baum, Christopher, Fehse, Boris
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834973/
https://ncbi.nlm.nih.gov/pubmed/19002163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.238
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