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Stem Cell Marking With Promotor-deprived Self-inactivating Retroviral Vectors Does Not Lead to Induced Clonal Imbalance
Stable genetic modification of stem cells holds great promise for gene therapy and marking, but commonly used γ-retroviral vectors were found to influence growth/survival characteristics of hematopoietic stem cells (HSCs) by insertional mutagenesis. In this article, we show that promoter-deprived γ-...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , , , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
Nature Publishing Group
2008
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2834973/ https://ncbi.nlm.nih.gov/pubmed/19002163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.238 |
| الوسوم: |
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