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Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects

Use of the pressure dependence of kinetic isotope effects, coupled with a study of their temperature dependence, as a probe for promoting motions in enzymatic hydrogen-tunneling reactions is reported. Employing morphinone reductase as our model system and by using stopped-flow methods, we measured t...

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Détails bibliographiques
Auteurs principaux: Hay, Sam, Sutcliffe, Michael J., Scrutton, Nigel S.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1766415/
https://ncbi.nlm.nih.gov/pubmed/17202258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608408104
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