Network of coupled promoting motions in enzyme catalysis

A network of coupled promoting motions in the enzyme dihydrofolate reductase is identified and characterized. The present identification is based on genomic analysis for sequence conservation, kinetic measurements of multiple mutations, and mixed quantum/classical molecular dynamics simulations of h...

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Detaylı Bibliyografya
Asıl Yazarlar: Agarwal, Pratul K., Billeter, Salomon R., Rajagopalan, P. T. Ravi, Benkovic, Stephen J., Hammes-Schiffer, Sharon
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2002
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC122427/
https://ncbi.nlm.nih.gov/pubmed/11867722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052005999
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