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pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16(INK4a) tumor suppressor gene
Genetic studies have demonstrated that Bmi1 promotes cell proliferation and stem cell self-renewal with a correlative decrease of p16(INK4a) expression. Here, we demonstrate that Polycomb genes EZH2 and BMI1 repress p16 expression in human and mouse primary cells, but not in cells deficient for pRB...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1759899/ https://ncbi.nlm.nih.gov/pubmed/17210787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1499407 |
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