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p53 binds to and is required for the repression of Arf tumor suppressor by HDAC and Polycomb
The expression of tumor suppressor Arf is tightly repressed during normal cell growth at a young age, and is activated by oncogenic insults and during aging, resulting in p53 activation and cell cycle arrest to prevent hyperproliferation. The mechanisms of both transcriptional repression and activat...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3227421/ https://ncbi.nlm.nih.gov/pubmed/21447739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3483 |
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