A new modified thrombin binding aptamer containing a 5′–5′ inversion of polarity site

The solution structure of a new modified thrombin binding aptamer (TBA) containing a 5′–5′ inversion of polarity site, namely d((3′)GGT(5′)-(5′)TGGTGTGGTTGG(3)′), is reported. NMR and CD spectroscopy, as well as molecular dynamic and mechanic calculations, have been used to characterize the 3D struc...

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Autores principales: Martino, Luigi, Virno, Ada, Randazzo, Antonio, Virgilio, Antonella, Esposito, Veronica, Giancola, Concetta, Bucci, Mariarosaria, Cirino, Giuseppe, Mayol, Luciano
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2006
Materias:
Structural Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751544/
https://ncbi.nlm.nih.gov/pubmed/17145716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl915
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