Thrombin–aptamer recognition: a revealed ambiguity

Aptamers are structured oligonucleotides that recognize molecular targets and can function as direct protein inhibitors. The best-known example is the thrombin-binding aptamer, TBA, a single-stranded 15-mer DNA that inhibits the activity of thrombin, the key enzyme of coagulation cascade. TBA folds...

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Bibliografiska uppgifter
Huvudupphovsmän: Russo Krauss, Irene, Merlino, Antonello, Giancola, Concetta, Randazzo, Antonio, Mazzarella, Lelio, Sica, Filomena
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2011
Ämnen:
Structural Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177225/
https://ncbi.nlm.nih.gov/pubmed/21715374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr522
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