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Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding
Mixed duplex/quadruplex oligonucleotides have attracted great interest as therapeutic targets as well as effective biomedical aptamers. In the case of thrombin-binding aptamer (TBA), the addition of a duplex motif to the G-quadruplex module improves the aptamer resistance to biodegradation and the a...
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| Published in: | Nucleic Acids Res |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4737158/ https://ncbi.nlm.nih.gov/pubmed/26673709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1384 |
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