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Crystallization and preliminary X-ray analysis of the complex of human α-thrombin with a modified thrombin-binding aptamer
The thrombin-binding aptamer (TBA) is a consensus DNA 15-mer that binds specifically to human α-thrombin at nanomolar concentrations and inhibits its procoagulant functions. Recently, a modified TBA (mTBA) containing a 5′–5′ inversion-of-polarity site has been shown to be more stable and to possess...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2917304/ https://ncbi.nlm.nih.gov/pubmed/20693681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110024632 |
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