Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity

Here we report investigations, based on circular dichroism, nuclear magnetic resonance spectroscopy, molecular modelling, differential scanning calorimetry and prothrombin time assay, on analogues of the thrombin binding aptamer (TBA) in which individual thymidines were replaced by 5-fluoro-2′-deoxy...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Nucleic Acids Res
Κύριοι συγγραφείς: Virgilio, Antonella, Petraccone, Luigi, Vellecco, Valentina, Bucci, Mariarosaria, Varra, Michela, Irace, Carlo, Santamaria, Rita, Pepe, Antonietta, Mayol, Luciano, Esposito, Veronica, Galeone, Aldo
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Oxford University Press 2015
Θέματα:
Chemical Biology and Nucleic Acid Chemistry
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678827/
https://ncbi.nlm.nih.gov/pubmed/26582916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1224
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