Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative

Many antiproliferative G-quadruplexes (G4s) arise from the folding of GT-rich strands. Among these, the Thrombin Binding Aptamer (TBA), as a rare example, adopts a monomolecular well-defined G4 structure. Nevertheless, the potential anticancer properties of TBA are severely hampered by its anticoagu...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Scuotto, Maria, Rivieccio, Elisa, Varone, Alessia, Corda, Daniela, Bucci, Mariarosaria, Vellecco, Valentina, Cirino, Giuseppe, Virgilio, Antonella, Esposito, Veronica, Galeone, Aldo, Borbone, Nicola, Varra, Michela, Mayol, Luciano
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652776/
https://ncbi.nlm.nih.gov/pubmed/26250112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv789
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